CBD and Prednisone for Dogs: Safety, Interactions & Side Effects

CBD and Prednisone for Dogs: Safety, Interactions & Side Effects
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Key Takeaways

  • CBD and prednisone work in different ways, but they’re both processed by the liver, so using them together means your vet needs to stay in the loop and help monitor things closely.
  • If your dog’s dealing with itching, restlessness, or stiffness, a combo of CBD and prednisone, when supervised, can offer balanced support.
  • Prednisone is powerful for calming inflammation and immune flare-ups, but can bring side effects like extra thirst, frequent peeing, or mood changes, especially if used long-term.
  • Stick with pet-specific CBD products that come with third-party lab testing to keep things safe, especially for chronic issues.
  • Bailey’s CBD has vet-formulated CBD options like calming oils, hip & joint blends, and tasty yummies that help support your dog’s wellness the natural way.

What Is CBD & How Is It Used for Dogs?

CBD, short for cannabidiol, is a compound found in hemp that’s been making waves in the pet world. Unlike THC, it won’t get your dog high. Instead, it’s often used to help dogs stay calm, feel more balanced, and deal with everyday stress. 

CBD interacts with the dog’s endocannabinoid system, which plays a role in things like mood and even skin health. Many pet parents notice their dogs seem more relaxed during car rides, loud noises, or big changes at home after adding CBD to their routine.

Benefits of CBD for Common Triggers

If your dog gets worked up during fireworks, seems restless in new places, or has skin discomfort, CBD might help take the edge off. It’s often used to support a more balanced and relaxed daily life.

CBD Safety Profile

CBD Side Effects

When used correctly, CBD is generally safe for dogs, especially when you choose a pet-specific product with no THC. Still, side effects can happen. 

Some dogs might get a bit sleepy, act a little off-balance, or show changes in appetite or thirst. Giving too much or using a low-quality product can increase the chances of problems. In rare cases, dogs can have stronger reactions like vomiting or extreme grogginess, especially if the product contains THC by mistake.

Choosing Safe & Quality CBD Products

To stay on the safe side, choose CBD brands that are transparent about what’s in their products. Always check for a Certificate of Analysis (COA) from a third-party lab; this shows the exact ingredients, cannabinoid levels, and confirms the absence of harmful substances like pesticides or heavy metals. 

A trustworthy brand, like Bailey’s CBD, not only shares these lab results openly but also holds a Department of Health license, which adds another level of credibility. Looking out for these details helps ensure you're giving your pet a clean, high-quality product made specifically for their needs.

Bailey's CBD: Natural Support for Your Pet's Wellness

Veterinarian-Formulated | USDA Organic Hemp | Lab-Tested

 

Tailored Wellness Options:

  • Calming Support Chews & Oil: Peanut butter-flavored soft chews that promote calmness during thunderstorms, travel, or separation – without causing drowsiness.
  • Hip & Joint Formula: Support your aging or active pet's mobility with our grain-free formula combining full-spectrum hemp extract with joint-supporting ingredients.
  • "No More Itchies" Probiotic Chews: Bacon-flavored soft chews that help maintain healthy skin and digestive balance for pets with seasonal sensitivities.

Why Pet Parents Choose Bailey's:

✓ Single-source USDA organic hemp from Boulder, CO
✓ Subcritical CO2 extraction for cleaner, high-quality CBD
✓ Full-spectrum formula (not isolate) for enhanced effectiveness
✓ Non-psychoactive (<0.3% THC)
✓ Backed by Dr. Robert J. Silver, DVM
✓ Third-party lab tested for heavy metals and pesticides (QR code on each package)
✓ Free from fillers, chemicals, and harmful additives
✓ Licensed by the Department of Health for added oversight
✓ 4.5 TrustScore from 1,533+ verified reviews on Trustpilot

Find Your Pet's Perfect Formula:

We offer multiple potencies for different sizes and needs – from tiny companions to gentle giants – ensuring the right support for every furry family member. Your satisfaction and your pet's wellness are our priority.

SHOP BAILEY'S CBD COLLECTION →

What Is Prednisone & How Is It Used for Dogs?

Prednisone is kind of the heavy hitter in a vet’s toolkit. It’s a synthetic steroid that helps calm inflammation and quiet the immune system when things go haywire. 

If your dog’s super itchy, swollen, or just not acting like themselves because they’re uncomfortable, prednisone is often used for support.

How Prednisone Works

It basically tells your dog’s immune system to chill out, which helps reduce swelling, itching, and pain across the body. It’s also part of the protocol in serious situations, like when a dog’s having a bad allergic reaction and needs quick relief.

Monitoring & Tapering

One big rule with prednisone: don’t stop it cold turkey. The body needs time to get its hormone balance back on track. That’s why your vet will always give you a tapering schedule when it’s time to reduce or stop the dose.

Just like we monitor our pets’ health, managing medications like prednisone requires careful attention and the right approach.

Prednisone Safety Profile

Short- & Long-Term Side Effects of Prednisone

Even a few days on prednisone can make your dog drink more, pee more, eat like they’re starving, or act a little wired. Some might slow down or have a queasy stomach.

If they’re on it longer, you might notice weight gain, muscle loss, or thinning fur. It can slow healing and make them more prone to infections. In some cases, it messes with blood sugar or causes conditions like Cushing’s. That’s why regular vet check-ins are key when prednisone is part of the routine.

Tips for Managing Prednisone Side Effects

Here are some ways you can manage your dogs' prednisone side effects:

  • Provide frequent bathroom breaks to avoid accidents
  • Do not restrict water intake, even if your dog drinks more
  • Monitor weight and avoid overfeeding
  • Keep routines calm and consistent to reduce stress

CBD & Prednisone: Potential Interactions

CBD and prednisone both get processed in your dog’s liver, using the same enzyme system. When CBD slows that system down, it can cause prednisone to hang around longer than it should, which might ramp up its effects more than intended.

Risks of Combining CBD & Prednisone

If prednisone builds up too much, your dog might start drinking and peeing more, acting hungrier than usual, or just seeming a bit off. Since both put some stress on the liver, it can also be a problem for pups with sensitive systems. 

And because they both affect mood and the immune system, combining them can lead to some unexpected reactions, like increased drowsiness, restlessness, or changes in appetite and behavior. 

In some cases, it might even make it harder to tell which medication is causing what effect, so close monitoring is key.

Veterinary Guidance Is Essential

This is definitely a “check with your vet first” kind of combo. They might tweak the doses, run a few tests, or just ask you to keep a close eye on how your dog’s doing. A little planning goes a long way in keeping things safe and smooth.

Always consult with your vet before combining CBD and prednisone to ensure your dog’s safety and well-being!

Practical Tips for Pet Owners

Thinking of combining CBD with prednisone? Check out these tips first:

  1. Choose Quality Products: Stick with CBD products made just for pets, and only the kind that’s been tested to make sure it’s clean, safe, and THC-free.
  2. Monitor Your Dog Closely: Jot down any changes in your dog’s mood, appetite, energy, or bathroom habits. It’ll help your vet spot anything early.
  3. Follow Dosage Instructions: Always follow your vet’s dosing instructions. Missed a prednisone dose? Don’t double up, just get back on schedule
  4. Schedule Regular Check-Ups: Routine vet visits and bloodwork go a long way in making sure everything’s working safely, especially with meds involved.
  5. Be Patient and Observant: Some side effects ease with time. Others might need a tweak in the routine. Watch closely and keep your vet in the loop.

Bailey’s CBD: The Trusted Choice for Your Dog’s Wellness

Dogs deal with a lot: restlessness, itching, stiff joints, and you want to give them the best support possible. That’s where Bailey’s CBD comes in. Everything we create is made with your pet’s well-being in mind, backed by years of experience and high standards you can count on.

Bailey’s CBD is here to help keep your dog feeling their best, with products made to support their health and happiness!

We start by sourcing our hemp from a single USDA organic farm to ensure consistent, high-quality ingredients in every batch. 

Then, we use a gentle subcritical CO₂ extraction method at a trusted lab in Boulder, Colorado; the only one in the U.S. offering this process. It’s a rare and careful approach that preserves all the beneficial compounds without using any harsh chemicals. The result is a cleaner CBD oil that supports your dog’s everyday wellness.

Bailey’s CBD is also licensed by the Department of Health, giving our products an added layer of safety and reliability that many brands can’t match. Each batch goes through third-party lab testing, checking for purity, potency, and any unwanted stuff like heavy metals or pesticides. It’s the kind of transparency that gives peace of mind.

These are some of our best-selling products:

  • CBD Oil for Dogs: Clean, straightforward blend with fractionated coconut oil that helps your dog's system absorb everything smoothly. No unnecessary fillers—just the good stuff in a handy dropper bottle.
  • Hip & Joint CBD Soft Chews: Yummy treats loaded with CBD-rich hemp, MSM, glucosamine, and green lipped mussel that may help maintain healthy joints. Your pup gets what feels like a treat while supporting their mobility.
  • CBD Paw & Nose Balm: Nourishing protection for those rough paw pads and dry noses, especially when dealing with tough surfaces like icy walks or hot asphalt. Creates a comforting barrier against the elements.
  • CBD Pet Shampoo: Mild, effective wash containing nourishing ingredients like organic aloe, avocado oil, and colloidal oatmeal extract that keep your dog's coat looking great and feeling silky smooth while being gentle on their skin's natural balance.

Getting started is simple! Each bottle of our CBD oil comes with clear dosage guidelines, so you’ll know exactly how much to give based on your dog’s size. Every product is made in the USA, grain-free, soy-free, and thoroughly tested to meet our high standards for quality.

Frequently Asked Questions (FAQ)

How does CBD help dogs with nervous behavior or itchy skin?

CBD taps into your dog’s endocannabinoid system, which helps to calm your pup down. Many pet parents notice their dogs seem more at ease after adding CBD to their routine, especially during stressful events or seasonal flare-ups.

How long should I wait after stopping prednisone before giving my dog CBD?

It depends on your dog’s situation, but most vets suggest waiting at least a day or two after finishing prednisone before starting CBD. If your dog’s been on steroids long-term, they may need more time to bounce back. Always check with your vet to make sure the transition is safe and smooth, especially since prednisone needs to be tapered, not stopped cold.

Will CBD make my dog sleepy like prednisone does?

Not quite. While prednisone can sometimes make dogs restless or oddly tired, CBD usually helps them feel calm without knocking them out. If your pup seems too sleepy after taking CBD, it could be a sign that the dose is a little too high or the formula isn’t the right match.

Is CBD legal for pets in all states?

Hemp-derived CBD with less than 0.3% THC is legal across the U.S., but some states still have their own laws. If you’re traveling, check local rules just to be safe. And always go with trusted brands that offer lab-tested, pet-specific products.

What types of CBD products does Bailey’s offer for dogs?

Bailey’s CBD has something for every pup, ranging from calming CBD oils to tasty CBD treats and even pet shampoo. All our products are vet-formulated, pet-friendly, and designed to help dogs stay chill, mobile, and happy.


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

These products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.

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