CBD with Hydroxyzine for Dogs: Safety, Interactions & Side Effects

Bailey's CBD: Natural Support for Your Pet's Wellness

Veterinarian-Formulated | USDA Organic Hemp | Lab-Tested

 

Tailored Wellness Options:

• Calming Support Chews & Oil: Peanut butter-flavored soft chews that promote calmness during thunderstorms, travel, or separation – without causing drowsiness.
• Hip & Joint Formula: Support your aging or active pet's mobility with our grain-free formula combining full-spectrum hemp extract with joint-supporting ingredients.
• "No More Itchies" Probiotic Chews: Bacon-flavored soft chews that help maintain healthy skin and digestive balance for pets with seasonal sensitivities.

Why Pet Parents Choose Bailey's:

✓ Single-source USDA organic hemp from Boulder, CO
✓ Subcritical CO₂ extraction for cleaner, high-quality CBD
✓ Full-spectrum formula (not isolate) for enhanced effectiveness
✓ Non-psychoactive (<0.3% THC)
✓ Backed by Dr. Robert J. Silver, DVM
✓ Third-party lab tested for heavy metals and pesticides (QR code on each package)
✓ Free from fillers, chemicals, and harmful additives
✓ Licensed by the Department of Health for added oversight
✓ 4.5 TrustScore from 1,533+ verified reviews on Trustpilot

Find Your Pet's Perfect Formula:

We offer multiple potencies for different sizes and needs – from tiny companions to gentle giants – ensuring the right support for every furry family member. Your satisfaction and your pet's wellness are our priority.

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Safety of Combining CBD & Hydroxyzine

Potential Drug Interactions

CBD and hydroxyzine can both help calm your dog, but combining them might make your pup overly drowsy or less alert. In rare cases, it could even affect breathing, especially if there are existing health issues. 

Since both are processed through the liver, CBD can slow how quickly hydroxyzine clears out, increasing its effects. This can also happen with other meds like painkillers, antibiotics, or anxiety drugs. Discuss with your vet before mixing CBD with anything else.

Recognizing Side Effects

With hydroxyzine, your dog might get sleepy, drink more water, or have a slightly upset stomach. CBD can do the same with a side of appetite change or restlessness, depending on the dog. 

Combine them, and you might see your pup more zonked than usual, a little wobbly, or breathing slower. If anything feels off, especially with breathing, get immediate medical attention for your pup. 

Keep an eye out for excessive sleepiness and other changes in your pup's behavior.

When to Seek Veterinary Help

Contact your veterinarian or an emergency clinic if your dog shows:

• Severe lethargy or inability to wake up
• Difficulty breathing
• Persistent vomiting or diarrhea
• Sudden changes in behavior or mobility

Dosage & Administration Guidelines

Hydroxyzine is usually dosed between 0.5 to 2 mg per kg every 6 to 8 hours; however, your vet will provide the exact dosage.

CBD is more flexible. A good starting or maintenance dose for dogs weighing 25 to 50 lbs is 5 mg twice daily, totaling 10 mg per day. 

This dosage can be adjusted depending on your dog's response, and you must consult your vet before starting or changing any medication or supplement routine.

Tips for Safe Administration

Stick with pet-specific products; don’t just grab any CBD off the shelf. Avoid anything with sketchy extras like xylitol or mystery flavorings. 

Shake liquid meds well, use a proper dosing tool, and never stop hydroxyzine suddenly if your dog’s been on it for a while. Your vet will guide you through any changes.

Monitoring Your Dog

Once you start either or both, pay close attention. Is your dog extra sleepy? Wobbly? Breathing weird? Not eating or drinking like usual? These are all things to watch for. If something feels off, call your vet, and if it’s serious, like trouble breathing, don’t wait; head to the emergency clinic!

Product Quality & Safety

CBD products can vary widely in quality, so it's important to know what to look for. Start by checking if the brand has the NASC (National Animal Supplement Council) quality seal, which signals a commitment to safety and manufacturing standards. Also, make sure the product includes a third-party lab report—this confirms exactly what’s inside and ensures it’s free from harmful levels of THC (anything over 0.3%) or unwanted contaminants.

At Bailey’s CBD, we go a step further by making our third-party lab results easy to access and proudly holding a Department of Health license; both of which add an extra layer of trust for pet owners. 

We believe in full transparency and quality you can count on. When choosing CBD, it’s important to avoid products with vague labels or ones that don’t clearly say they’re made specifically for pets.

Special Considerations

If your dog is young, old, pregnant, or has health issues (like heart, liver, or kidney problems), they’ll need extra care and closer monitoring. Long-term use can be safe, but regular vet check-ins are a must to make sure everything’s still working as it should.

Pregnant dogs and other vulnerable pups need extra monitoring and veterinary care.

Practical Tips for Pet Owners

Start low and go slow; there’s no need to rush. Keep a quick journal or notes on how your dog’s doing day by day. And don’t forget: store everything safely out of reach of curious noses and paws.

Why Bailey’s CBD is the Best Choice for Your Dog

That’s why Bailey’s CBD focuses on helping pets feel calm, comfortable, and mobile, even during those tough moments like thunderstorms, occasional discomfort in movement, or sensitivity in their skin.

For nearly a decade, pet parents across the country have turned to Bailey’s for reliable support backed by science and transparency.

Bailey's CBD has been helping dogs stay calm through storms, house guests, and everyday stress for nearly a decade.

What makes us different starts with where we get our hemp. It comes from a single USDA organic farm, so we know exactly what’s going into every product. Then we use a gentle subcritical CO₂ extraction process at a specialized lab in Boulder, Colorado. It’s actually the only lab in the U.S. that uses this method, which helps keep all the good stuff in and leaves out anything harsh.

Every batch is tested for things like heavy metals and pesticides, and we share those results, so you know exactly what your pet is getting.

Bailey’s also runs under a Department of Health license, which means our operations are held to higher standards than most brands in the pet CBD space. Each formula features all-natural, human-grade ingredients without grains, GMOs, or anything artificial.

Our CBD oils and soft chews are designed to support your dog’s day-to-day life. For more restless moments, like travel or loud weather, the Calming CBD Oil adds soothing ingredients like chamomile and L-theanine. When joints need some love, the Hip & Joint CBD Oil blends CBD with turmeric, glucosamine, and other natural helpers that keep your pup moving with ease.

Giving Bailey’s is simple. You can mix the oil into food or give it directly. The soft chews work great as a treat, too. 

We offer soothing topicals like CBD-infused shampoos and balms to nourish and protect the skin and coat. In addition to our dog products, we also provide CBD options specially made for cats and horses, so every pet can feel their best. Every product reflects the same care, quality, and honesty that Bailey’s is known for.

Choosing Bailey’s means giving your pet thoughtful support every day; trusted by vets, loved by families, and focused on helping your best friend feel their best.

Frequently Asked Questions (FAQ)

How long should I wait between giving my dog CBD and hydroxyzine?

To play it safe, spacing them out by about 4 to 6 hours is usually a good idea. This helps avoid doubling up on sedation. Because every dog metabolizes things differently, your vet might suggest a specific timing that works best, maybe CBD in the evening and hydroxyzine earlier in the day.

Can I use CBD oil and hydroxyzine together for my dog's severe thunderstorm phobia?

In some cases, yes, but only with your vet’s approval. For dogs with serious storm restlessness, the combo might be part of a bigger plan that also includes safe spaces, calming soundtracks, and behavior training. It’s best to try the combo during a calm day first, just to see how your dog reacts before using it during an actual storm.

Are there any breeds that should never take CBD with hydroxyzine?

Some breeds need extra caution. Dogs with the MDR1 gene mutation; like Collies, Aussies, Shelties, and similar mixes can react strongly to many meds.

Flat-faced breeds like Bulldogs or Pugs may also have breathing issues that could be made worse by sedation. And some dogs, like Yorkies or Dobermans, may have liver sensitivities.

If your dog is in one of these groups, chat with your vet before trying this combo. Genetic testing and a customized plan might be the safest route.

Which Bailey’s CBD products are best for dogs with nervous behavior or mobility challenges?

Bailey’s Calming CBD Oil for Dogs and Calming CBD Yummies are great for dogs needing calmness, while the Hip & Joint CBD Oil and Hip & Joint CBD Soft Chews can improve your dog’s mobility. Check out our lineup here!

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.