CBD vs Apoquel for Dogs: Differences, Benefits, Side Effects & Dosage
Comparing CBD and Apoquel for an itchy dog involves understanding very different products. This guide reviews uses, side effects, and care questions so you can discuss options with your veterinarian without replacing or changing prescribed medication independently.
Key Takeaways
- CBD is not an alternative to Apoquel. Apoquel is a prescription medication for allergic itch; CBD is a wellness supplement that supports healthy skin, calm behavior, and everyday comfort.
- Apoquel works fast to stop itching, but long-term use can mess with your dog’s immune system.
- CBD works with your dog's endocannabinoid system to support normal immune function and everyday comfort; it does not suppress the immune system.
- Apoquel is a prescription drug with precise dosing, while CBD products vary widely, so choosing a high-quality, vet-recommended brand is important.
- Bailey’s CBD delivers full-spectrum oils and soft chews made just for pets, supporting skin, joints, calm behavior, and overall health naturally.
CBD vs Apoquel: What Dog Owners Need to Know Right Now
If your dog won’t stop scratching, you may be wondering how a prescription like Apoquel differs from a wellness supplement like CBD. They are not interchangeable: Apoquel treats allergic itch, while CBD supports everyday skin and coat health and calm behavior. Knowing what each one is for helps you have a better conversation with your veterinarian.
What Are Apoquel and CBD?
Apoquel is a fast-acting prescription med that targets enzymes behind allergic itching and inflammation. It works well, but it also suppresses part of your dog’s immune system. CBD, on the other hand, is a plant-based option that supports the body’s natural balance by working with the endocannabinoid system. It is not a medication and does not treat allergies; it supports normal immune function and overall balance.
Bailey's CBD: Natural Support for Your Pet's Wellness
Veterinarian-Formulated | USDA Organic Hemp | Lab-Tested
What pet parents say
Browse customer feedback using the review arrows, or read all reviews on Trustpilot.
Tailored Wellness Options:
- Calming Support Chews & Oil: Peanut butter-flavored soft chews that promote calmness during thunderstorms, travel, or separation – without causing drowsiness.
- Hip & Joint Formula: Support your aging or active pet's mobility with our grain-free formula combining full-spectrum hemp extract with joint-supporting ingredients.
- "No More Itchies" Probiotic Chews: Bacon-flavored soft chews that help maintain healthy skin and digestive balance for pets with seasonal sensitivities.
Why Pet Parents Choose Bailey's:
✓ Subcritical CO2 extraction for cleaner, high-quality CBD
✓ Full-spectrum formula (not isolate) for enhanced effectiveness
✓ Non-psychoactive (<0.3% THC)
✓ Backed by Dr. Robert J. Silver, DVM
✓ Third-party lab tested for heavy metals and pesticides (QR code on each package)
✓ Free from fillers, chemicals, and harmful additives
✓ Licensed by the Department of Health for added oversight
✓ 4.5 TrustScore from 1,533+ verified reviews on Trustpilot
Find Your Pet's Perfect Formula:
We offer multiple potencies for different sizes and needs – from tiny companions to gentle giants – ensuring the right support for every furry family member. Your satisfaction and your pet's wellness are our priority.
Shop All ProductsKey Differences Between CBD and Apoquel
|
Feature |
Apoquel |
CBD |
|
Mechanism |
Suppresses immune system enzymes to reduce symptoms quickly |
Supports normal immune function and everyday comfort |
|
Symptom Approach |
Masks symptoms like itching and redness without addressing root causes |
Supports overall balance; does not treat symptoms or allergies |
|
Speed of Action |
Fast-acting, often within hours |
Wellness support builds gradually with consistent daily use |
|
Side Effects |
Potentially severe: infections, gastrointestinal issues, urinary tract infections, and possible increased risk of cancer |
Generally non-toxic with fewer and milder side effects reported |
|
Immune Impact |
Suppresses immune function, which may weaken natural defenses |
Supports and balances immune function without suppression |
Benefits of Apoquel and CBD for Dogs
Apoquel Benefits:
- Fast relief from itching, redness, and scratching
- Often prescribed by vets for quick symptom control
CBD Benefits:
- Supports healthy skin and coat

- Promotes overall balance and supports calm behavior
- Non-toxic with fewer serious side effects
- Can pair well with natural ingredients like turmeric for added support
Common Side Effects
Apoquel Side Effects:
- Higher risk of infections like ear and urinary tract issues
- Possible vomiting or diarrhea
- Long-term use may suppress the immune system and raise cancer concerns
- Lethargy and appetite changes may also occur
CBD Side Effects:
- Usually mild, like drowsiness or slight digestive upset
- No known serious risks when using quality, pet-specific products
Dosage Guidelines
Apoquel Dosage: Apoquel isn’t a one-size-fits-all med; it’s prescribed based on your dog’s weight and symptoms. Most pups start with it twice a day, then taper down to once daily as things improve. Because it can have some serious side effects, your vet will need to keep a close eye on things.
CBD Dosage: CBD is a bit more flexible. You’ll want to start with a low dose based on your dog’s size and gradually increase it while watching how they respond. It’s usually given by mouth or added to food. Just make sure you’re using a high-quality product made specifically for pets to keep things safe and effective.
Considerations for Use
- Apoquel is great for fast relief, but can raise concerns about immune suppression and long-term risks.
- CBD is a wellness supplement that supports overall balance; it is not a treatment for allergies.
- Some pet parents give CBD alongside Apoquel for everyday wellness support, but only under a vet's guidance.
- Diet matters too! Switching to fresh or raw foods may help tackle itchy skin from the inside out.
Giving your dog the best with Bailey’s CBD
Helping your dog feel their best shouldn’t be complicated. At Bailey’s, we make it simple with natural CBD products that support calm, comfort, and overall health, without any junk.

We use one of the cleanest extraction methods out there: subcritical CO₂ extraction. It’s gentle, chemical-free, and done by the only lab in the country that meets our standards. That means your pet gets the full benefit of cannabinoids and terpenes, preserved just as nature intended.
Our CBD is single-sourced from a trusted farm in Boulder, Colorado, so every batch is consistent and traceable. We also operate under a Department of Health license, something many CBD brands can’t say. Each product is tested by third-party labs for purity, potency, and safety.
Bailey’s CBD Oil for Dogs is available in strengths ranging from 150 mg to 600 mg and is made with just two ingredients: full-spectrum hemp and fractionated coconut oil. It’s simple to dose and supports calm behavior, healthy skin, and joint comfort. Our Omega Hemp CBD Soft Chews offer a flavorful, vegan-friendly way to support skin health, mobility, and overall balance, so it’s great for dogs of all sizes.
No matter if it’s our easy-to-use CBD oil or tasty soft chews packed with calming and skin-loving ingredients, everything’s designed with your pup in mind. We even have options for cats and horses, plus soothing balms for extra support.
With Bailey’s, you’re not just getting CBD; you’re getting peace of mind.
Frequently Asked Questions
Can I give my dog CBD and Apoquel at the same time?
Yes, just make sure your vet is in the loop. Apoquel handles the allergic itch, while CBD supports everyday wellness. CBD is not a reason to change the Apoquel dose; only your vet should adjust a prescription. Since both are processed by the liver, your vet may want to keep an eye on liver enzymes if you're using them long-term.
Are there specific dog breeds that do better with one or the other?
Not officially, but some patterns pop up. Whether Apoquel is right for your dog is a decision for your veterinarian. CBD can be used as everyday wellness support for any breed; it depends on your dog's unique needs.
What quality indicators should I look for when buying CBD for my dog?
Go for brands that offer third-party lab results and use organic hemp. Bonus points for pet-specific formulas and gentle extraction methods like CO₂. Bailey’s CBD nails all of these and more.
Can either one cure my dog's allergies permanently?
Nope, unfortunately, there’s no magic cure. Apoquel is a prescription that manages allergic itch; CBD does not treat allergies but can support skin and coat health as part of the routine. Pair your vet's plan with diet tweaks and trigger avoidance for the best long-term results.
Why should I choose Bailey’s CBD for my dog?
Bailey’s CBD has been helping pet parents for nearly a decade with vet-formulated, high-quality products that are thoroughly tested and thoughtfully made. It’s safe, effective, and trusted by dog lovers who want the very best for their pups.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
These products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.